Lackawanna Blues

S. Epatha Merkerson
Rachel "Nanny" Crosby

Marcus Carl Franklin
Ruben Santiago Jr.

Yasiin Bey
The Bandleader

Carmen Ejogo
Alean

Louis Gossett Jr.
Ol'lem Taylor

Macy Gray
Pauline

Terrence Howard
Bill Crosby

Ernie Hudson
Dick Barrymore

Rosie Perez
Bertha

Liev Schreiber
Ulysses Ford

Jimmy Smits
Ruben Santiago Sr.

Patricia Wettig
Laura's Mother

Jeffrey Wright
Mr. Paul

Adina Porter
Ricky

Jana Thompson
Hotel Receptionist in Toronto

Bill Simms Jr.
Self

Ruben Santiago-Hudson
Freddie Cobbs

Charlayne Woodard
Bill's Woman

Omar Benjamin
Ruben, Jr. - Toddler

Julie Benz
Laura

Robert Bradley
Otis McClanahan

Michael Kenneth Williams
Jimmy